Protein: Q9Y6I3 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9Y6I3 (Uniprot)	EPN1_HUMAN	EPN1	Epsin-1	human	Yes

Protein Function

Uniprot: Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.

Dissimilar Functions Manual Curation

Function 1: Binds to membranes. Regulates receptor-mediated endocytosis. Condition: cytoplasm or cell membrane localisation.

Function 2: Binds PLZF transcription factor. Condition: nuclear localisation (import via interaction with PLZF, export via interaction with CRM1)

Publications (PMID): 10791968, 11425879

MoonDB Network Modules

Biological Processes

Showing 1 to 3 of 3 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
134	GO:0044267	cellular protein metabolic process
134	GO:0060255	regulation of macromolecule metabolic process
134	GO:0007165	signal transduction

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Cellular Components

Showing 1 to 5 of 5 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
134	GO:0005829	cytosol
134	GO:0005634	nucleus
368	GO:0005829	cytosol
368	GO:0005634	nucleus
368	GO:0031982	vesicle

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Protein GO Annotations

Biological Processes

Showing 1 to 7 of 7 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001701	in utero embryonic development	IEA
GO:0006897	endocytosis	IEA
GO:0007219	Notch signaling pathway	IEA
GO:0007565	female pregnancy	IEA
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	TAS
GO:0048568	embryonic organ development	IEA
GO:0061024	membrane organization	TAS

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Cellular Components

Showing 1 to 4 of 4 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IEA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	TAS
GO:0005905	clathrin-coated pit	IEA

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 1 of 1 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165

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All Protein Interactions

Showing 1 to 10 of 14 entries

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Interactor	Also a MoonDB EMF protein
CE126_HUMAN	No
DAZP2_HUMAN	Yes: Q15038 (MoonDB)
DPYL1_HUMAN	No
EPS15_HUMAN	Yes: P42566 (MoonDB)
LAPM5_HUMAN	No
LITAF_HUMAN	No
MED31_HUMAN	No
PKHB2_HUMAN	No
REPS2_HUMAN	No
RNF11_HUMAN	No

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Publications Associated

Showing 1 to 10 of 20 entries

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PMID	Article Title
10557078	Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis.
10764745	Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation.
12775724	RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.
12836669	Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15057824	The DNA sequence and biology of human chromosome 19.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16516836	Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly.
16964243	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17081983	Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 9 of 9 entries

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Domain Name	Domain ID	Source
ENTH	IPR013809	InterPro
ENTH	PF01417	Pfam
ENTH	PS50942	PROSITE
ENTH	SM00273	SMART
ENTH_VHS	IPR008942	InterPro
SSF48464	SSF48464	SUPFAM
UIM	PS50330	PROSITE
UIM	SM00726	SMART
UIM_dom	IPR003903	InterPro

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