Protein: Q14160 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q14160 (Uniprot)	SCRIB_HUMAN	SCRIB	Protein scribble homolog	human	No

Protein Function

Uniprot: Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	255	GO:0006139	nucleobase-containing compound metabolic process	694	1.10e-111	5.07e-25
GO:0010646	regulation of cell communication	284	GO:0006139	nucleobase-containing compound metabolic process	694	6.71e-28	7.52e-07

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
22	GO:0019538	protein metabolic process
22	GO:0007165	signal transduction
41	GO:0007165	signal transduction
139	GO:0023051	regulation of signaling
139	GO:0007165	signal transduction
186	GO:0048468	cell development
186	GO:0007166	cell surface receptor signaling pathway
186	GO:0044267	cellular protein metabolic process
186	GO:0035556	intracellular signal transduction
186	GO:0030182	neuron differentiation

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
22	GO:0005576	extracellular region
22	GO:0005886	plasma membrane
22	GO:0031982	vesicle
41	GO:0030054	cell junction
41	GO:0044459	plasma membrane part
101	GO:0005829	cytosol
101	GO:0043232	intracellular non-membrane-bounded organelle
186	GO:0005829	cytosol
186	GO:0005886	plasma membrane
186	GO:0031982	vesicle

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001843	neural tube closure	IMP
GO:0001921	positive regulation of receptor recycling	IMP
GO:0007268	chemical synaptic transmission	IBA
GO:0008283	cell proliferation	IDA
GO:0016080	synaptic vesicle targeting	IEA
GO:0016477	cell migration	IMP
GO:0021747	cochlear nucleus development	IEA
GO:0035089	establishment of apical/basal cell polarity	IMP
GO:0039502	suppression by virus of host type I interferon-mediated signaling pathway	IEA
GO:0039563	suppression by virus of host STAT1 activity	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005654	nucleoplasm	IDA
GO:0005886	plasma membrane	IDA
GO:0005911	cell-cell junction	IDA
GO:0005913	cell-cell adherens junction	IDA
GO:0008328	ionotropic glutamate receptor complex	IBA
GO:0014069	postsynaptic density	IBA
GO:0016323	basolateral plasma membrane	IBA
GO:0030027	lamellipodium	IEA
GO:0030054	cell junction	IDA
GO:0031252	cell leading edge	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005654	nucleoplasm	GO:0005886	plasma membrane	9.14e-199	6.17e-196
GO:0005654	nucleoplasm	GO:0005911	cell-cell junction	3.44e-02	2.10e-14
GO:0005654	nucleoplasm	GO:0016323	basolateral plasma membrane	7.74e-03	2.03e-05
GO:0005654	nucleoplasm	GO:0030054	cell junction	3.08e-04	1.38e-34
GO:0005654	nucleoplasm	GO:0045211	postsynaptic membrane	4.67e-04	3.99e-53
GO:0005654	nucleoplasm	GO:0070062	extracellular exosome	3.37e-20	1.23e-35

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ACTN1_HUMAN	No
ACTN2_HUMAN	No
ACTN3_HUMAN	No
ACTN4_HUMAN	No
ADA1D_HUMAN	No
ADA22_HUMAN	No
ANR50_HUMAN	No
APC_HUMAN	No
ARHG7_HUMAN	No
ARHG8_HUMAN	No

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Publications Associated

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PMID	Article Title
8590280	Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.
11027293	Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase.
12168954	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
15144186	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
15182672	Mammalian Scribble forms a tight complex with the betaPIX exchange factor.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15649318	The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus.
15775968	Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1-ARF6 pathway.
15806148	Junctional recruitment of mammalian Scribble relies on E-cadherin engagement.
15975580	hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells.

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OMIM Diseases Associated

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OMIM ID	Disease Name
182940	Neural tube defects

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Protein Domains Associated

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Domain Name	Domain ID	Source
Leu-rich_rpt	IPR001611	InterPro
Leu-rich_rpt_typical-subtyp	IPR003591	InterPro
LRR	PS51450	PROSITE
LRR_8	PF13855	Pfam
LRR_dom_sf	IPR032675	InterPro
LRR_TYP	SM00369	SMART
PDZ	IPR001478	InterPro
PDZ	PF00595	Pfam
PDZ	PS50106	PROSITE
PDZ	SM00228	SMART

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