Protein: Q13480 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q13480 (Uniprot)	GAB1_HUMAN	GAB1	GRB2-associated-binding protein 1	human	No

Protein Function

Uniprot: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).

MoonDB Dissimilar Functions

Showing 1 to 3 of 3 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007166	cell surface receptor signaling pathway	108	GO:0034641	cellular nitrogen compound metabolic process	35	5.53e-55	9.57e-64
GO:0010646	regulation of cell communication	284	GO:0034641	cellular nitrogen compound metabolic process	35	1.59e-39	2.52e-03
GO:0034641	cellular nitrogen compound metabolic process	35	GO:0007165	signal transduction	355	4.22e-144	6.90e-18

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 38 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
35	GO:0044271	cellular nitrogen compound biosynthetic process
35	GO:0044267	cellular protein metabolic process
35	GO:0090304	nucleic acid metabolic process
35	GO:0010468	regulation of gene expression
35	GO:0009966	regulation of signal transduction
108	GO:0007167	enzyme linked receptor protein signaling pathway
108	GO:0006139	nucleobase-containing compound metabolic process
108	GO:0031325	positive regulation of cellular metabolic process
108	GO:1902533	positive regulation of intracellular signal transduction
108	GO:0010604	positive regulation of macromolecule metabolic process

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Cellular Components

Showing 1 to 10 of 13 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
35	GO:0005829	cytosol
35	GO:0005634	nucleus
35	GO:0005886	plasma membrane
108	GO:0005829	cytosol
108	GO:0005634	nucleus
108	GO:0005886	plasma membrane
111	GO:0005829	cytosol
111	GO:0005886	plasma membrane
187	GO:0005829	cytosol
187	GO:0005886	plasma membrane

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Protein GO Annotations

Biological Processes

Showing 1 to 10 of 15 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001525	angiogenesis	IMP
GO:0007173	epidermal growth factor receptor signaling pathway	TAS
GO:0007411	axon guidance	TAS
GO:0008283	cell proliferation	TAS
GO:0008286	insulin receptor signaling pathway	TAS
GO:0031532	actin cytoskeleton reorganization	IMP
GO:0035728	response to hepatocyte growth factor	IEA
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	IEA
GO:0038084	vascular endothelial growth factor signaling pathway	IMP
GO:0038089	positive regulation of cell migration by vascular endothelial growth factor signaling pathway	ISS

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Cellular Components

Showing 1 to 1 of 1 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005829	cytosol	TAS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 61 entries

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Interactor	Also a MoonDB EMF protein
BCAR3_HUMAN	No
BLK_HUMAN	No
BLNK_HUMAN	No
BTK_HUMAN	No
CRK_HUMAN	Yes: P46108 (MoonDB)
CRKL_HUMAN	No
EGFR_HUMAN	Yes: P00533 (MoonDB)
FES_HUMAN	No
GAB2_HUMAN	No
GRAP2_HUMAN	No

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Publications Associated

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PMID	Article Title
8596638	A Grb2-associated docking protein in EGF- and insulin-receptor signalling.
12475979	Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1.
12486104	Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15010462	Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15815621	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15863030	Cellular signaling by fibroblast growth factor receptors.
16959974	The consensus coding sequences of human breast and colorectal cancers.
18669648	A quantitative atlas of mitotic phosphorylation.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 7 of 7 entries

Search:

Domain Name	Domain ID	Source
PH	PF00169	Pfam
PH	SM00233	SMART
PH-like_dom_sf	IPR011993	InterPro
PH_domain	IPR001849	InterPro
PH_DOMAIN	PS50003	PROSITE
S68442	S68442	PIR
SSF50729	SSF50729	SUPFAM

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