Protein: Q00987 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q00987 (Uniprot)	MDM2_HUMAN	MDM2	E3 ubiquitin-protein ligase Mdm2	human	No

Protein Function

Uniprot: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuc more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	1, 187	GO:0006725	cellular aromatic compound metabolic process	53, 222, 342	5.44e-126	5.27e-27
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	270, 874	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1	GO:0035556	intracellular signal transduction
1	GO:0032268	regulation of cellular protein metabolic process
1	GO:0043067	regulation of programmed cell death
1	GO:0009966	regulation of signal transduction
53	GO:0006139	nucleobase-containing compound metabolic process
53	GO:0016567	protein ubiquitination
53	GO:0060255	regulation of macromolecule metabolic process
99	GO:0031325	positive regulation of cellular metabolic process
99	GO:0010628	positive regulation of gene expression
99	GO:0051173	positive regulation of nitrogen compound metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
1	GO:0005829	cytosol
1	GO:0005634	nucleus
53	GO:0005829	cytosol
53	GO:0005654	nucleoplasm
99	GO:0005654	nucleoplasm
125	GO:0005829	cytosol
125	GO:0005634	nucleus
131	GO:0005829	cytosol
131	GO:0043232	intracellular non-membrane-bounded organelle
131	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA
GO:0001568	blood vessel development	IEA
GO:0001974	blood vessel remodeling	IEA
GO:0002027	regulation of heart rate	IEA
GO:0003181	atrioventricular valve morphogenesis	IEA
GO:0003203	endocardial cushion morphogenesis	IEA
GO:0003281	ventricular septum development	IEA
GO:0003283	atrial septum development	IEA
GO:0006461	protein complex assembly	IDA
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	TAS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IMP
GO:0005654	nucleoplasm	TAS
GO:0005730	nucleolus	IDA
GO:0005737	cytoplasm	IMP
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	TAS
GO:0016604	nuclear body	IDA
GO:0030666	endocytic vesicle membrane	TAS
GO:0043234	protein complex	IDA
GO:0045202	synapse	IEA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0030666	endocytic vesicle membrane	1.59e-05	7.63e-18
GO:0005634	nucleus	GO:0045202	synapse	1.10e-08	8.94e-15
GO:0005654	nucleoplasm	GO:0005886	plasma membrane	9.14e-199	6.17e-196
GO:0005654	nucleoplasm	GO:0045202	synapse	3.30e-10	4.22e-25
GO:0005730	nucleolus	GO:0005886	plasma membrane	7.70e-47	3.09e-07
GO:0005886	plasma membrane	GO:0016604	nuclear body	1.42e-38	3.32e-172

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
A4_HUMAN	No
ACM3_HUMAN	No
AKT1_HUMAN	No
ANR17_HUMAN	No
ARF_HUMAN	No
ARHG6_HUMAN	No
ARRB1_HUMAN	Yes: P49407 (MoonDB)
ARRB2_HUMAN	Yes: P32121 (MoonDB)
ATF4_HUMAN	No
BAIP2_HUMAN	No

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Publications Associated

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PMID	Article Title
1614537	Amplification of a gene encoding a p53-associated protein in human sarcomas.
7651818	A functional p53-responsive intronic promoter is contained within the human mdm2 gene.
7689721	Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes.
8705862	Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.
8875929	Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
9270029	Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein.
9450543	Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53.
10597303	A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein.
10608892	Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein.
10611322	Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
Mdm2	IPR028340	InterPro
MDM2	PIRSF500700	PIRSF
MDM2_E3_ligase	IPR015459	InterPro
p53_MDM_2/4	PIRSF006748	PIRSF
p53_neg-reg_MDM_2/4	IPR016495	InterPro
PTHR13844:SF15	PTHR13844:SF15	PANTHER
S24354	S24354	PIR
SSF47592	SSF47592	SUPFAM
SSF90209	SSF90209	SUPFAM
SWIB	PF02201	Pfam

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