Protein: P14921 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P14921 (Uniprot)	ETS1_HUMAN	ETS1	Protein C-ets-1	human	No

Protein Function

Uniprot: Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial c more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	169	GO:0006725	cellular aromatic compound metabolic process	736	5.44e-126	5.27e-27

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
169	GO:0030522	intracellular receptor signaling pathway
169	GO:0045892	negative regulation of transcription, DNA-templated
169	GO:0045944	positive regulation of transcription from RNA polymerase II promoter
169	GO:0043401	steroid hormone mediated signaling pathway
172	GO:0060255	regulation of macromolecule metabolic process
341	GO:0070887	cellular response to chemical stimulus
341	GO:0045893	positive regulation of transcription, DNA-templated
341	GO:0006357	regulation of transcription from RNA polymerase II promoter
429	GO:0016070	RNA metabolic process
429	GO:0034645	cellular macromolecule biosynthetic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
169	GO:0005654	nucleoplasm
341	GO:0005654	nucleoplasm
429	GO:0070013	intracellular organelle lumen
429	GO:0005634	nucleus
736	GO:0005829	cytosol
736	GO:0070013	intracellular organelle lumen
736	GO:0044428	nuclear part

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001666	response to hypoxia	IEA
GO:0006955	immune response	TAS
GO:0007565	female pregnancy	IEA
GO:0008284	positive regulation of cell proliferation	IEA
GO:0008285	negative regulation of cell proliferation	TAS
GO:0009612	response to mechanical stimulus	IEA
GO:0010595	positive regulation of endothelial cell migration	IMP
GO:0010715	regulation of extracellular matrix disassembly	IEA
GO:0021854	hypothalamus development	IEA
GO:0021983	pituitary gland development	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005667	transcription factor complex	IEA
GO:0005737	cytoplasm	IEA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005667	transcription factor complex	GO:0005737	cytoplasm	9.09e-11	9.47e-68

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ACAD8_HUMAN	No
ALEX_HUMAN	No
ANDR_HUMAN	Yes: P10275 (MoonDB)
APLP2_HUMAN	No
AR6P4_HUMAN	No
ARI4B_HUMAN	No
BCD1_HUMAN	No
CA052_HUMAN	No
CDC5L_HUMAN	No
CENPB_HUMAN	No

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Publications Associated

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PMID	Article Title
1614856	Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter.
2847145	Mammalian ets-1 and ets-2 genes encode highly conserved proteins.
2997781	The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active.
3060801	Structure, expression and alternative splicing of the human c-ets-1 proto-oncogene.
8231246	Quantitative and qualitative variation of ETS-1 transcripts in hematologic malignancies.
8521493	The solution structure of the human ETS1-DNA complex reveals a novel mode of binding and true side chain intercalation.
9333025	Modulation of ETS-1 transcriptional activity by huUBC9, a ubiquitin-conjugating enzyme.
10698492	EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes.
11909962	Sp100 interacts with ETS-1 and stimulates its transcriptional activity.
15247905	SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
Ets	PF00178	Pfam
ETS	SM00413	SMART
Ets_dom	IPR000418	InterPro
ETS_DOMAIN_1	PS00345	PROSITE
ETS_DOMAIN_2	PS00346	PROSITE
ETS_DOMAIN_3	PS50061	PROSITE
ETSDOMAIN	PR00454	PRINTS
PNT	PS51433	PROSITE
Pointed_dom	IPR003118	InterPro
SAM/pointed_sf	IPR013761	InterPro

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