Protein: O95166 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O95166 (Uniprot)	GBRAP_HUMAN	GABARAP	Gamma-aminobutyric acid receptor-associated protein	human	No

Protein Function

Uniprot: Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in aut more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0019538	protein metabolic process	404	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	467	1.88e-02	4.66e-37

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
404	GO:0044267	cellular protein metabolic process
404	GO:0007165	signal transduction
467	GO:0000398	mRNA splicing, via spliceosome
467	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

Showing 1 to 4 of 4 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
404	GO:0005829	cytosol
404	GO:0012505	endomembrane system
404	GO:0031982	vesicle
467	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

Showing 1 to 9 of 9 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000045	autophagosome assembly	IBA
GO:0000226	microtubule cytoskeleton organization	IEA
GO:0000422	autophagy of mitochondrion	IBA
GO:0006605	protein targeting	TAS
GO:0006995	cellular response to nitrogen starvation	IBA
GO:0007268	chemical synaptic transmission	TAS
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IDA
GO:0016236	macroautophagy	TAS
GO:0097352	autophagosome maturation	TAS

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Cellular Components

Showing 1 to 10 of 15 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000139	Golgi membrane	IEA
GO:0000421	autophagosome membrane	TAS
GO:0005764	lysosome	IEA
GO:0005776	autophagosome	IDA
GO:0005790	smooth endoplasmic reticulum	IEA
GO:0005829	cytosol	TAS
GO:0005874	microtubule	IEA
GO:0005875	microtubule associated complex	IEA
GO:0005886	plasma membrane	IEA
GO:0005930	axoneme	ISS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
AES_HUMAN	Yes: Q08117 (MoonDB)
ATG13_HUMAN	No
ATG4B_HUMAN	No
ATGA1_HUMAN	No
CALR_HUMAN	No
DMPK_HUMAN	No
GBRG2_HUMAN	No
HDAC5_HUMAN	No
KBTB6_HUMAN	No
MLH1_HUMAN	No

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Publications Associated

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PMID	Article Title
9892355	GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton.
10931946	Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.
11096062	The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3.
11146101	Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.
11729197	The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein.
11825910	Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.
11875056	Solution structure of human GABA(A) receptor-associated protein GABARAP: implications for biological function and its regulation.
11885988	1H, 13C and '5N resonance assignments of GABARAP, GABAA receptor associated protein.
12507496	GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3.
15169837	LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 6 of 6 entries

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Domain Name	Domain ID	Source
Atg8	PF02991	Pfam
Atg8-like	IPR004241	InterPro
GABARAP	cd01611	CDD
PTHR10969	PTHR10969	PANTHER
SSF54236	SSF54236	SUPFAM
Ubiquitin-like_domsf	IPR029071	InterPro

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