Protein: O43639 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O43639 (Uniprot)	NCK2_HUMAN	NCK2	Cytoplasmic protein NCK2	human	No

Protein Function

Uniprot: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.

MoonDB Dissimilar Functions

Showing 1 to 4 of 4 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0002376	immune system process	111	GO:0006396	RNA processing	681	1.36e-06	3.84e-29
GO:0007165	signal transduction	187	GO:0006396	RNA processing	681	3.78e-31	3.47e-84
GO:0010646	regulation of cell communication	284	GO:0006396	RNA processing	681	4.71e-17	5.67e-104
GO:0036211	protein modification process	423, 555	GO:0006396	RNA processing	681	5.60e-03	3.14e-16

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
44	GO:0010467	gene expression
44	GO:0031324	negative regulation of cellular metabolic process
44	GO:0009889	regulation of biosynthetic process
44	GO:0060255	regulation of macromolecule metabolic process
111	GO:0006955	immune response
111	GO:0035556	intracellular signal transduction
111	GO:0009967	positive regulation of signal transduction
111	GO:0006468	protein phosphorylation
111	GO:0060255	regulation of macromolecule metabolic process
111	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
44	GO:0005829	cytosol
44	GO:0005634	nucleus
104	GO:0005829	cytosol
104	GO:0005815	microtubule organizing center
105	GO:0005634	nucleus
111	GO:0005829	cytosol
111	GO:0005886	plasma membrane
187	GO:0005829	cytosol
187	GO:0005886	plasma membrane
254	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001771	immunological synapse formation	IEA
GO:0007015	actin filament organization	IEA
GO:0007165	signal transduction	TAS
GO:0007172	signal complex assembly	NAS
GO:0007173	epidermal growth factor receptor signaling pathway	TAS
GO:0007176	regulation of epidermal growth factor-activated receptor activity	TAS
GO:0008285	negative regulation of cell proliferation	TAS
GO:0016477	cell migration	IEA
GO:0030032	lamellipodium assembly	IEA
GO:0030838	positive regulation of actin filament polymerization	IMP

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Cellular Components

Showing 1 to 5 of 5 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005737	cytoplasm	IDA
GO:0005783	endoplasmic reticulum	IDA
GO:0005829	cytosol	TAS
GO:0012506	vesicle membrane	IEA
GO:0014069	postsynaptic density	IEA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 132 entries

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Interactor	Also a MoonDB EMF protein
A0A0C4DGW7_HUMAN	No
ABI2_HUMAN	Yes: Q9NYB9 (MoonDB)
ABI3_HUMAN	No
ANR55_HUMAN	No
ATN1_HUMAN	No
BC11A_HUMAN	No
BCAP_HUMAN	No
BCAR1_HUMAN	No
CBLB_HUMAN	No
CC120_HUMAN	No

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Publications Associated

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PMID	Article Title
9737977	Identification of Nck family genes, chromosomal localization, expression, and signaling specificity.
9843575	Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways.
10026169	Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.
10330411	Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: a role in cytoskeletal remodeling.
11240126	Identification and kinetic analysis of the interaction between Nck-2 and DOCK180.
12470648	Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16337946	Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1.
16835242	Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress.
18088087	Phosphoproteome of resting human platelets.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 25 entries

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Domain Name	Domain ID	Source
Cytoplasmic_NCK	PIRSF037874	PIRSF
NCK	IPR017304	InterPro
Nck2_SH2	IPR035883	InterPro
Nck2_SH3_1	IPR035559	InterPro
Nck2_SH3_2	IPR035560	InterPro
Nck2_SH3_3	IPR035561	InterPro
SH2	IPR000980	InterPro
SH2	PF00017	Pfam
SH2	PS50001	PROSITE
SH2	SM00252	SMART

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