Protein: Q9NPI8 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9NPI8 (Uniprot)	FANCF_HUMAN	FANCF	Fanconi anemia group F protein	human	No

Protein Function

Uniprot: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity).

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007166	cell surface receptor signaling pathway	108	GO:0006139	nucleobase-containing compound metabolic process	462	6.88e-41	1.21e-84

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MoonDB Network Modules

Biological Processes

Showing 1 to 7 of 7 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
108	GO:0007167	enzyme linked receptor protein signaling pathway
108	GO:0006139	nucleobase-containing compound metabolic process
108	GO:0031325	positive regulation of cellular metabolic process
108	GO:1902533	positive regulation of intracellular signal transduction
108	GO:0010604	positive regulation of macromolecule metabolic process
108	GO:0006468	protein phosphorylation
462	GO:0090304	nucleic acid metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
108	GO:0005829	cytosol
108	GO:0005634	nucleus
108	GO:0005886	plasma membrane
462	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001541	ovarian follicle development	IEA
GO:0007283	spermatogenesis	IEA
GO:0008150	biological_process	ND
GO:0016567	protein ubiquitination	IEA
GO:0036297	interstrand cross-link repair	TAS

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Cellular Components

Showing 1 to 2 of 2 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005654	nucleoplasm	TAS
GO:0043240	Fanconi anaemia nuclear complex	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 8 of 8 entries

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Interactor	Also a MoonDB EMF protein
FANCA_HUMAN	Yes: O15360 (MoonDB)
FANCE_HUMAN	No
FANCG_HUMAN	Yes: O15287 (MoonDB)
HES1_HUMAN	No
MARK3_HUMAN	No
NOE2_HUMAN	No
PPP5_HUMAN	No
PSF2_HUMAN	No

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Publications Associated

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PMID	Article Title
10615118	The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM.
11063725	The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG.
12724401	A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15502827	X-linked inheritance of Fanconi anemia complementation group B.
16116422	A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.
17082180	Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex.
18550849	HES1 is a novel interactor of the Fanconi anemia core complex.

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OMIM Diseases Associated

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OMIM ID	Disease Name
603467	Fanconi anemia complementation group F

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Protein Domains Associated

Showing 1 to 5 of 5 entries

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Domain Name	Domain ID	Source
FANCF	IPR035428	InterPro
FANCF	PF11107	Pfam
FANCF_met	IPR025825	InterPro
PD321645	PD321645	ProDom
PTHR14449	PTHR14449	PANTHER

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