Protein: Q9NP31 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9NP31 (Uniprot)	SH22A_HUMAN	SH2D2A	SH2 domain-containing protein 2A	human	No

Protein Function

Uniprot: Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KD more..

MoonDB Dissimilar Functions

Showing 1 to 1 of 1 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007166	cell surface receptor signaling pathway	108	GO:0006139	nucleobase-containing compound metabolic process	132	6.88e-41	1.21e-84

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 26 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
108	GO:0007167	enzyme linked receptor protein signaling pathway
108	GO:0006139	nucleobase-containing compound metabolic process
108	GO:0031325	positive regulation of cellular metabolic process
108	GO:1902533	positive regulation of intracellular signal transduction
108	GO:0010604	positive regulation of macromolecule metabolic process
108	GO:0006468	protein phosphorylation
111	GO:0006955	immune response
111	GO:0035556	intracellular signal transduction
111	GO:0009967	positive regulation of signal transduction
111	GO:0006468	protein phosphorylation

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Cellular Components

Showing 1 to 9 of 9 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
108	GO:0005829	cytosol
108	GO:0005634	nucleus
108	GO:0005886	plasma membrane
111	GO:0005829	cytosol
111	GO:0005886	plasma membrane
132	GO:0005634	nucleus
171	GO:0005829	cytosol
171	GO:0005886	plasma membrane
357	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

Showing 1 to 6 of 6 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001525	angiogenesis	IEA
GO:0007165	signal transduction	TAS
GO:0008283	cell proliferation	IEA
GO:0009967	positive regulation of signal transduction	IEA
GO:0030154	cell differentiation	IEA
GO:0048010	vascular endothelial growth factor receptor signaling pathway	TAS

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Cellular Components

Showing 1 to 2 of 2 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005737	cytoplasm	TAS
GO:0005829	cytosol	TAS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 35 entries

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Interactor	Also a MoonDB EMF protein
ANDR_HUMAN	Yes: P10275 (MoonDB)
ARI5A_HUMAN	No
ASB3_HUMAN	No
CQ082_HUMAN	No
CRK_HUMAN	Yes: P46108 (MoonDB)
DC121_HUMAN	No
DP13A_HUMAN	Yes: Q9UKG1 (MoonDB)
EGFR_HUMAN	Yes: P00533 (MoonDB)
ERBB2_HUMAN	Yes: P04626 (MoonDB)
FA46A_HUMAN	No

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Publications Associated

Showing 1 to 8 of 8 entries

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PMID	Article Title
9468509	Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites.
10692392	VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor.
10752626	The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15592455	Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
15962004	VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis.
16710414	The DNA sequence and biological annotation of human chromosome 1.
18669648	A quantitative atlas of mitotic phosphorylation.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 9 of 9 entries

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Domain Name	Domain ID	Source
SH2	IPR000980	InterPro
SH2	PF00017	Pfam
SH2	PS50001	PROSITE
SH2	SM00252	SMART
SH2_dom_sf	IPR036860	InterPro
SH2_SH2D2A	cd10416	CDD
SH2D2A_SH2	IPR035884	InterPro
SH2DOMAIN	PR00401	PRINTS
SSF55550	SSF55550	SUPFAM

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