Protein: Q8N0Z3 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q8N0Z3 (Uniprot)	SPICE_HUMAN	SPICE1	Spindle and centriole-associated protein 1	human	No

Protein Function

Uniprot: Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.

MoonDB Dissimilar Functions

Showing 1 to 4 of 4 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	142	GO:0051641	cellular localization	872	4.17e-16	1.54e-157
GO:0006725	cellular aromatic compound metabolic process	57	GO:0051641	cellular localization	872	2.74e-17	6.15e-158
GO:0009059	macromolecule biosynthetic process	662	GO:0051641	cellular localization	872	1.95e-13	6.68e-127
GO:0044260	cellular macromolecule metabolic process	591, 714	GO:0051641	cellular localization	872	4.50e-03	3.02e-89

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 27 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
3	GO:0022607	cellular component assembly
3	GO:0060255	regulation of macromolecule metabolic process
37	GO:0007165	signal transduction
57	GO:0006139	nucleobase-containing compound metabolic process
142	GO:0090304	nucleic acid metabolic process
142	GO:0060255	regulation of macromolecule metabolic process
275	GO:0022607	cellular component assembly
275	GO:0006796	phosphate-containing compound metabolic process
275	GO:0060255	regulation of macromolecule metabolic process
275	GO:0007165	signal transduction

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Cellular Components

Showing 1 to 10 of 40 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
3	GO:0044430	cytoskeletal part
3	GO:0005829	cytosol
3	GO:0005634	nucleus
37	GO:0005829	cytosol
57	GO:0005634	nucleus
101	GO:0005829	cytosol
101	GO:0043232	intracellular non-membrane-bounded organelle
104	GO:0005829	cytosol
104	GO:0005815	microtubule organizing center
142	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

Showing 1 to 4 of 4 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0046599	regulation of centriole replication	IMP
GO:0051301	cell division	IEA
GO:0051310	metaphase plate congression	IMP
GO:0090307	mitotic spindle assembly	IMP

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Cellular Components

Showing 1 to 3 of 3 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005813	centrosome	IDA
GO:0005814	centriole	IDA
GO:0005819	spindle	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 129 entries

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Interactor	Also a MoonDB EMF protein
ADIP_HUMAN	Yes: Q9Y2D8 (MoonDB)
AMOT_HUMAN	No
ARI1B_HUMAN	No
BAF_HUMAN	No
BTF3_HUMAN	No
C2CD3_HUMAN	No
C2D1A_HUMAN	No
CAMP1_HUMAN	No
CAMP2_HUMAN	No
CC138_HUMAN	No

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Publications Associated

Showing 1 to 9 of 9 entries

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PMID	Article Title
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17081983	Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17974005	The full-ORF clone resource of the German cDNA consortium.
18669648	A quantitative atlas of mitotic phosphorylation.
19413330	Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332	Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231	Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20736305	SPICE -- a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression.
23186163	Toward a comprehensive characterization of a human cancer cell phosphoproteome.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 2 of 2 entries

Search:

Domain Name	Domain ID	Source
SPICE	PF15678	Pfam
SPICE1	IPR031387	InterPro

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