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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q13596
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q13596 (Uniprot)
SNX1_HUMAN
SNX1
Sorting nexin-1
human
No
Protein Function
Uniprot:
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retrom
er mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498).
more..
MoonDB Dissimilar Functions
Showing 1 to 1 of 1 entries
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0033036
macromolecule localization
517
GO:0006139
nucleobase-containing compound metabolic process
527
4.58e-19
9.70e-72
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MoonDB Network Modules
Biological Processes
Showing 1 to 6 of 6 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
79
GO:0007165
signal transduction
517
GO:0008104
protein localization
517
GO:0019538
protein metabolic process
521
GO:0060255
regulation of macromolecule metabolic process
527
GO:0090304
nucleic acid metabolic process
527
GO:0060255
regulation of macromolecule metabolic process
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Cellular Components
Showing 1 to 10 of 12 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
34
GO:0005634
nucleus
79
GO:0005634
nucleus
176
GO:0016021
integral component of membrane
176
GO:0031090
organelle membrane
350
GO:0012505
endomembrane system
350
GO:0031224
intrinsic component of membrane
517
GO:0005829
cytosol
517
GO:0012505
endomembrane system
517
GO:0031982
vesicle
521
GO:0070013
intracellular organelle lumen
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Protein GO Annotations
Biological Processes
Showing 1 to 7 of 7 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0006886
intracellular protein transport
IMP
GO:0016050
vesicle organization
IBA
GO:0031623
receptor internalization
IMP
GO:0034498
early endosome to Golgi transport
IMP
GO:0042147
retrograde transport, endosome to Golgi
NAS
GO:0045732
positive regulation of protein catabolic process
IEA
GO:0072673
lamellipodium morphogenesis
IDA
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Cellular Components
Showing 1 to 10 of 15 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005737
cytoplasm
IDA
GO:0005764
lysosome
IDA
GO:0005768
endosome
IDA
GO:0005794
Golgi apparatus
IEA
GO:0005829
cytosol
IEA
GO:0010008
endosome membrane
IDA
GO:0016020
membrane
IDA
GO:0019898
extrinsic component of membrane
IBA
GO:0030027
lamellipodium
IEA
GO:0030904
retromer complex
IDA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 23 entries
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Interactor
Also a MoonDB EMF protein
ACHG_HUMAN
No
AR6P1_HUMAN
No
ARFP2_HUMAN
No
ATRAP_HUMAN
No
ATX7_HUMAN
No
CKLF5_HUMAN
No
EGFR_HUMAN
Yes:
P00533 (MoonDB)
FUND1_HUMAN
No
KITH_HUMAN
No
MPC2_HUMAN
No
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Publications Associated
Showing 1 to 10 of 32 entries
Search:
PMID
Article Title
8638121
Enhanced degradation of EGF receptors by a sorting nexin, SNX1.
9819414
Identification of a family of sorting nexin molecules and characterization of their association with receptors.
11102511
Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes.
11997453
Endosomal localization and function of sorting nexin 1.
12198132
The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation.
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15498486
Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides.
15673616
Determinants of the endosomal localization of sorting nexin 1.
16407403
An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 17 entries
Search:
Domain Name
Domain ID
Source
AH/BAR_dom_sf
IPR027267
InterPro
G02522
G02522
PIR
Phox
IPR001683
InterPro
PTHR10555:SF129
PTHR10555:SF129
PANTHER
PX
PF00787
Pfam
PX
PS50195
PROSITE
PX
SM00312
SMART
PX_dom_sf
IPR036871
InterPro
PX_SNX1
IPR034901
InterPro
PX_SNX1
cd07281
CDD
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