Protein: Q13387 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q13387 (Uniprot)	JIP2_HUMAN	MAPK8IP2	C-Jun-amino-terminal kinase-interacting protein 2	human	No

Protein Function

Uniprot: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, t more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0034641	cellular nitrogen compound metabolic process	595	GO:0007165	signal transduction	828	4.22e-144	6.90e-18

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 31 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
21	GO:0060255	regulation of macromolecule metabolic process
333	GO:0060255	regulation of macromolecule metabolic process
333	GO:0009966	regulation of signal transduction
410	GO:0010467	gene expression
410	GO:0007165	signal transduction
544	GO:0016070	RNA metabolic process
544	GO:0006464	cellular protein modification process
544	GO:0006796	phosphate-containing compound metabolic process
544	GO:0031325	positive regulation of cellular metabolic process
544	GO:0010604	positive regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
333	GO:0016021	integral component of membrane
333	GO:0098590	plasma membrane region
410	GO:0005634	nucleus
544	GO:0005829	cytosol
544	GO:0005634	nucleus
555	GO:0005634	nucleus
560	GO:0005829	cytosol
595	GO:0005654	nucleoplasm
828	GO:0016021	integral component of membrane
828	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001662	behavioral fear response	ISS
GO:0007172	signal complex assembly	TAS
GO:0007254	JNK cascade	IEA
GO:0007617	mating behavior	IEA
GO:0010469	regulation of receptor activity	ISS
GO:0032874	positive regulation of stress-activated MAPK cascade	IEA
GO:0035176	social behavior	ISS
GO:0046328	regulation of JNK cascade	IDA
GO:0046958	nonassociative learning	ISS
GO:0048813	dendrite morphogenesis	ISS

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Cellular Components

Showing 1 to 4 of 4 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005737	cytoplasm	IDA
GO:0014069	postsynaptic density	ISS
GO:0043025	neuronal cell body	IEA
GO:0043234	protein complex	IEA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 77 entries

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Interactor	Also a MoonDB EMF protein
1C03_HUMAN	No
1C07_HUMAN	No
ADRB2_HUMAN	Yes: P07550 (MoonDB)
AFG32_HUMAN	No
ANGP1_HUMAN	No
APC10_HUMAN	No
ASGL1_HUMAN	No
ASPP2_HUMAN	No
BBS10_HUMAN	No
C1QT3_HUMAN	No

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Publications Associated

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PMID	Article Title
9110174	Large-scale concatenation cDNA sequencing.
10490659	The JIP group of mitogen-activated protein kinase scaffold proteins.
10591208	The DNA sequence of human chromosome 22.
10756100	cDNA cloning and mapping of a novel islet-brain/JNK interacting protein.
11378392	Fibroblast growth factor homologous factors are intracellular signaling proteins.
12529303	Reevaluating human gene annotation: a second-generation analysis of chromosome 22.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 12 entries

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Domain Name	Domain ID	Source
JIP2_SH3	IPR035637	InterPro
PH-like_dom_sf	IPR011993	InterPro
PID	PF00640	Pfam
PID	PS01179	PROSITE
PTB	SM00462	SMART
PTB/PI_dom	IPR006020	InterPro
SH3	PS50002	PROSITE
SH3	SM00326	SMART
SH3_9	PF14604	Pfam
SH3_domain	IPR001452	InterPro

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