Protein: P51668 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P51668 (Uniprot)	UB2D1_HUMAN	UBE2D1	Ubiquitin-conjugating enzyme E2 D1	human	No

Protein Function

Uniprot: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53 more..

MoonDB Dissimilar Functions

Showing 1 to 1 of 1 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	270	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 19 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
53	GO:0006139	nucleobase-containing compound metabolic process
53	GO:0016567	protein ubiquitination
53	GO:0060255	regulation of macromolecule metabolic process
125	GO:0044248	cellular catabolic process
125	GO:0016567	protein ubiquitination
125	GO:0060255	regulation of macromolecule metabolic process
270	GO:0034645	cellular macromolecule biosynthetic process
270	GO:0010467	gene expression
270	GO:0090304	nucleic acid metabolic process
270	GO:0032446	protein modification by small protein conjugation

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Cellular Components

Showing 1 to 10 of 11 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
53	GO:0005829	cytosol
53	GO:0005654	nucleoplasm
125	GO:0005829	cytosol
125	GO:0005634	nucleus
270	GO:0005829	cytosol
270	GO:0070013	intracellular organelle lumen
270	GO:0005634	nucleus
359	GO:0005634	nucleus
375	GO:0005829	cytosol
375	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

Showing 1 to 10 of 21 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS
GO:0000209	protein polyubiquitination	IDA
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS
GO:0002756	MyD88-independent toll-like receptor signaling pathway	TAS
GO:0006511	ubiquitin-dependent protein catabolic process	IDA
GO:0016567	protein ubiquitination	TAS
GO:0016579	protein deubiquitination	TAS
GO:0030509	BMP signaling pathway	TAS
GO:0031145	anaphase-promoting complex-dependent catabolic process	TAS
GO:0031398	positive regulation of protein ubiquitination	IDA

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Cellular Components

Showing 1 to 5 of 5 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000151	ubiquitin ligase complex	IDA
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	TAS
GO:0043234	protein complex	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 120 entries

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Interactor	Also a MoonDB EMF protein
AMFR_HUMAN	No
ANXA1_HUMAN	No
ANXA7_HUMAN	No
ARI2_HUMAN	No
ARRD3_HUMAN	No
BFAR_HUMAN	No
BIRC2_HUMAN	No
BIRC3_HUMAN	No
BIRC7_HUMAN	No
BIRC8_HUMAN	No

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Publications Associated

Showing 1 to 10 of 17 entries

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PMID	Article Title
8090726	Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.
9362508	Functional expression cloning and characterization of SFT, a stimulator of Fe transport.
11389839	Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.
12480712	UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis.
14562029	The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15164054	The DNA sequence and comparative analysis of human chromosome 10.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17588522	E3-independent monoubiquitination of ubiquitin-binding proteins.
18042044	Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 9 of 9 entries

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Domain Name	Domain ID	Source
I39202	I39202	PIR
SSF54495	SSF54495	SUPFAM
UBCc	cd00195	CDD
UBIQUITIN_CONJUGAT_1	PS00183	PROSITE
UBIQUITIN_CONJUGAT_2	PS50127	PROSITE
UBQ-conjugat_E2	IPR000608	InterPro
UBQ-conjugating_AS	IPR023313	InterPro
UBQ-conjugating_enzyme/RWD	IPR016135	InterPro
UQ_con	PF00179	Pfam

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