Protein: P32835 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P32835 (Uniprot)	GSP1_YEAST	GSP1	GTP-binding nuclear protein GSP1/CNR1	yeast	No

Protein Function

Uniprot: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Essential for cell viability. By analogy with Ras, Ran may be activated when GTP is exchanged for bound GDP by RCC1 and inactivated when GTP is hydrolyzed by Ran upon activatio more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0008104	protein localization	1184	GO:0044260	cellular macromolecule metabolic process	1268, 1275	7.50e-19	5.37e-13

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1184	GO:0034613	cellular protein localization
1268	GO:0016070	RNA metabolic process
1268	GO:0051656	establishment of organelle localization
1268	GO:0010467	gene expression
1268	GO:0071426	ribonucleoprotein complex export from nucleus
1275	GO:0016070	RNA metabolic process
1275	GO:0034613	cellular protein localization
1275	GO:0051649	establishment of localization in cell
1275	GO:0010467	gene expression

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
1184	GO:0005634	nucleus
1268	GO:0005634	nucleus
1275	GO:0044428	nuclear part

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000054	ribosomal subunit export from nucleus	IBA
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP
GO:0006606	protein import into nucleus	IBA
GO:0006913	nucleocytoplasmic transport	TAS
GO:0006997	nucleus organization	ISS
GO:0031938	regulation of chromatin silencing at telomere	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	TAS

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005737	cytoplasm	5.14e-51	7.30e-86

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
CSE1_YEAST	No
IMA1_YEAST	No
IMB1_YEAST	No
IMB4_YEAST	No
JSN1_YEAST	Yes: P47135 (MoonDB)
MOG1_YEAST	No
NTF2_YEAST	No
NUP2_YEAST	No
RCC1_YEAST	No
RRP44_YEAST	No

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Publications Associated

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PMID	Article Title
7687541	Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily.
7895733	Protein identifications for a Saccharomyces cerevisiae protein database.
8455603	GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization.
8896453	Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1.
9169871	The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.
11523802	Functional analysis of the yeast Ran exchange factor Prp20p: in vivo evidence for the RanGTP gradient model.
11589573	Overexpression of Bud5p can suppress mutations in the Gsp1p guanine nucleotide exchange factor Prp20p in Saccharomyces cerevisiae.
14729571	A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits.
15665377	Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.
17203074	Cex1p is a novel cytoplasmic component of the Saccharomyces cerevisiae nuclear tRNA export machinery.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
GTPRANTC4	PR00627	PRINTS
P-loop_NTPase	IPR027417	InterPro
PTHR24071	PTHR24071	PANTHER
RAN	PS51418	PROSITE
Ran_GTPase	IPR002041	InterPro
Ras	PF00071	Pfam
S35504	S35504	PIR
small_GTP	TIGR00231	TIGRFAMs
Small_GTP-bd_dom	IPR005225	InterPro
Small_GTPase	IPR001806	InterPro

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