Protein: P32325 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P32325 (Uniprot)	DBF4_YEAST	DBF4	DDK kinase regulatory subunit DBF4	yeast	No

Protein Function

Uniprot: Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	1141	GO:0009059	macromolecule biosynthetic process	1198	3.10e-17	2.99e-04

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
906	GO:0022402	cell cycle process
1141	GO:0044248	cellular catabolic process
1141	GO:1903047	mitotic cell cycle process
1141	GO:0090304	nucleic acid metabolic process
1141	GO:2000112	regulation of cellular macromolecule biosynthetic process
1141	GO:0010468	regulation of gene expression
1141	GO:0019219	regulation of nucleobase-containing compound metabolic process
1198	GO:0034645	cellular macromolecule biosynthetic process
1198	GO:0006464	cellular protein modification process
1198	GO:0090304	nucleic acid metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
906	GO:0005634	nucleus
1141	GO:0044427	chromosomal part
1141	GO:0005634	nucleus
1198	GO:0043232	intracellular non-membrane-bounded organelle
1198	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001100	negative regulation of exit from mitosis	IMP
GO:0006270	DNA replication initiation	IPI
GO:0006279	premeiotic DNA replication	IMP
GO:0007059	chromosome segregation	IEA
GO:0033314	mitotic DNA replication checkpoint	IGI
GO:0045860	positive regulation of protein kinase activity	IDA
GO:0051301	cell division	IEA
GO:0060903	positive regulation of meiosis I	IMP
GO:0071902	positive regulation of protein serine/threonine kinase activity	IMP
GO:1903468	positive regulation of DNA replication initiation	IGI

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Cellular Components

Showing 1 to 4 of 4 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000775	chromosome, centromeric region	IDA
GO:0000785	chromatin	IDA
GO:0005634	nucleus	IEA
GO:0031431	Dbf4-dependent protein kinase complex	IPI

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 7 of 7 entries

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Interactor	Also a MoonDB EMF protein
ATG17_YEAST	No
CDC5_YEAST	No
CDC7_YEAST	Yes: P06243 (MoonDB)
CDK1_YEAST	Yes: P00546 (MoonDB)
GAC1_YEAST	No
MCM2_YEAST	No
RAD53_YEAST	No

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Publications Associated

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PMID	Article Title
1514326	Genetic and molecular analysis of DNA43 and DNA52: two new cell-cycle genes in Saccharomyces cerevisiae.
1592236	Temperature-sensitive cdc7 mutations of Saccharomyces cerevisiae are suppressed by the DBF4 gene, which is required for the G1/S cell cycle transition.
8066465	Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo.
8474449	Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein.
8789263	Nucleotide sequence analysis of a 32,500 bp region of the right arm of Saccharomyces cerevisiae chromosome IV.
8943332	A novel role for Cdc5p in DNA replication.
9169867	The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
10330168	Cell cycle regulation of DNA replication initiator factor Dbf4p.
10373538	Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability.
12441400	An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 7 of 7 entries

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Domain Name	Domain ID	Source
Dfp1_Him1_M	PF08630	Pfam
Regulatory_Dfp1/Him1	IPR013939	InterPro
S25371	S25371	PIR
zf-DBF	PF07535	Pfam
ZF_DBF4	PS51265	PROSITE
Znf_DBF	IPR006572	InterPro
ZnF_DBF	SM00586	SMART

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