Protein: P15303 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P15303 (Uniprot)	SEC23_YEAST	SEC23	Protein transport protein SEC23	yeast	No

Protein Function

Uniprot: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SEC23 interacts with BET3 in more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	1004	GO:0016192	vesicle-mediated transport	1134	1.23e-52	1.21e-92

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1004	GO:0090304	nucleic acid metabolic process
1134	GO:0048193	Golgi vesicle transport
1134	GO:0022607	cellular component assembly
1134	GO:0034613	cellular protein localization
1134	GO:0051649	establishment of localization in cell
1134	GO:0043933	macromolecular complex subunit organization
1134	GO:0015031	protein transport

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
1004	GO:0005634	nucleus
1134	GO:0005783	endoplasmic reticulum

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0003400	regulation of COPII vesicle coating	IDA
GO:0006886	intracellular protein transport	IEA
GO:0006888	ER to Golgi vesicle-mediated transport	IEA
GO:0016236	macroautophagy	IMP
GO:0043547	positive regulation of GTPase activity	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000139	Golgi membrane	IEA
GO:0005789	endoplasmic reticulum membrane	IEA
GO:0030127	COPII vesicle coat	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
SEC16_YEAST	Yes: P48415 (MoonDB)
SEC24_YEAST	No
SEC31_YEAST	No
SFB2_YEAST	No
SFB3_YEAST	No

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Publications Associated

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PMID	Article Title
1498369	Sec23p and a novel 105-kDa protein function as a multimeric complex to promote vesicle budding and protein transport from the endoplasmic reticulum.
2188733	Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway.
2670558	Yeast Sec23p acts in the cytoplasm to promote protein transport from the endoplasmic reticulum to the Golgi complex in vivo and in vitro.
3049622	Reconstitution of protein transport from the endoplasmic reticulum to the Golgi complex in yeast: the acceptor Golgi compartment is defective in the sec23 mutant.
3293799	Reconstitution of SEC gene product-dependent intercompartmental protein transport.
6996832	Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway.
7026045	Order of events in the yeast secretory pathway.
7593161	Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p.
7925484	Multicopy STS1 restores both protein transport and ribosomal RNA stability in a new yeast sec23 mutant allele.
8451644	Requirement for a GTPase-activating protein in vesicle budding from the endoplasmic reticulum.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 24 entries

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Domain Name	Domain ID	Source
ADF-H/Gelsolin-like_dom_sf	IPR029006	InterPro
BVBY23	S05742	PIR
Gelsolin	PF00626	Pfam
Gelsolin-like_dom	IPR007123	InterPro
Gelsolin-like_dom_sf	IPR036180	InterPro
PTHR11141	PTHR11141	PANTHER
Sec23	IPR037364	InterPro
Sec23/24_helical_dom	IPR006900	InterPro
Sec23/24_helical_dom_sf	IPR036175	InterPro
Sec23/24_trunk_dom	IPR006896	InterPro

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